Sulfasalazine Delayed Release Tablets USP belong to the aminosalicylate class of anti-inflammatory medicines. They are designed with a special coating that allows the drug to release slowly in the intestines, reducing stomach irritation and improving effectiveness.

Mechanism of Action:

Sulfasalazine is broken down in the colon into 5-aminosalicylic acid (5-ASA) and sulfapyridine.

• 5-ASA reduces inflammation in the bowel.

• Sulfapyridine contributes to the therapeutic effect in rheumatoid arthritis.

Indications:

• Treatment of ulcerative colitis (reduces inflammation, prevents relapse)

• Management of Crohn’s disease (in selected cases)

• Treatment of rheumatoid arthritis in patients not responding well to other medicines

• Sometimes used in juvenile idiopathic arthritis

Dosage & Administration:

• Taken orally, after meals to reduce stomach upset.

• Dose depends on age, weight, and medical condition.

• Delayed-release tablets must be swallowed whole—not crushed or chewed.

Precautions:

• Not recommended in patients allergic to sulfa drugs or salicylates.

• Use with caution in liver/kidney disease.

• Regular monitoring of blood counts and liver function may be required.

• Should be used with medical supervision during pregnancy and breastfeeding.

Possible Side Effects:

• Loss of appetite, nausea, vomiting

• Headache, dizziness

• Rash, fever (allergic reaction in some patients)

• Rare: low blood counts, liver problems